Bone Mineral Content in Nephrotic Children on Long-Term, Alternate-Day Prednisone Therapy
- 1 May 1995
- journal article
- research article
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 34 (5) , 234-236
- https://doi.org/10.1177/000992289503400501
Abstract
Bone mineral content (BMC) was measured by single-photon absorptiometry in 24 children with steroid-dependent, minimal-lesion nephrotic syndrome after 1 to 6.3 years of alternate-day prednisone therapy and in a sex- and age-matched control group. Bone mineral content was -0.002 ± 1.2 standard deviation scores in patients and 0.3 ± 1.4 in controls ( t = 1.17; P = 0.25). No significant relation was found between BMC in patients and the amount of prednisone taken or the duration of therapy. Alternate-day prednisone therapy at doses usually needed to keep children with steroid-dependent nephrotic syndrome under control does not significantly affect BMC.Keywords
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