FURTHER-STUDIES ON H-2 LINKED DEPENDENCE OF ADJUVANT ACTION OF BRUCELLA-ABORTUS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (5) , 807-814
Abstract
The B 19S strain of B. abortus acts as an adjuvant to the anti-sheep red blood cell (SRBC) reaction in some congenic strains of mice but not in others. If the recipient is H-2b, there is no adjuvant effect (B 19S); neither is there [thymus-dependent (T)] anti-B 19S reaction as measured by thymocyte activation and change of electrophoretic mobility. There is as strong a thymus-independent anti-B 19S reaction (production of hemagglutinins) as in the H-2b mice as in the others. Experiments with T cell deprived mice show that the adjuvant action of B 19S is thymus-dependent. As the anti-SRBC reaction without adjuvant is also thymus-dependent, it is difficult to distinguish anti-SRBC and anti-B 19S reactions from the adjuvant action of B 19S on the anti-SRBC reaction. Several explanations are possible, all involving H-2 (Ir?) controlled thymus dependent mechanisms.