Abstract
A recent writer1has remarked that our position in the study of thyroid disease is about what it would be in regard to diabetes if we were without our laboratory data relative to the urine and the blood. It is well known2that in some very severe cases of thyrotoxicosis the thyroid gland is not definitely palpable, or at most not more so than in very many presumably healthy persons. This emphasizes the fundamental importance, if any emphasis were needed, of looking beyond the goiter for clinical data more distinctive and more strongly diagnostic than the clinical signs and symptoms usually present in thyroid intoxication. Recent observations have confirmed the suspicion long entertained that other endocrine glands besides the thyroid play a more or less important rôle in exophthalmic goiter. This is especially true with reference to the thymus, the importance of which would almost seem to justify

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