STUDIES ON THE INTERRELATIONSHIPS OF THE ADRENAL CORTEX AND RENAL AMMONIA EXCRETION BY THE RAT1

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Abstract
The kidney of the adrenalectomized rat inhibits defects in capacity to excrete ammonia and titratable acid amounting, respectively, to 50% and nearly 80% of the normal. These defects are apparent under usual laboratory conditions and under conditions of mild and severe acid stress. They become apparent within a few hours following adrenalectomy and persist unchanged over the period of 2 weeks to 2 months encompassed in this study. They may be corrected by the admn. of adequate doses of desoxycorticosterone acetate or whole adrenal cortical extract and probably result from some specific depression in tubular metabolic activities. As a consequence of the depression of these tubular activities, the adrenalectomized animal maintained in otherwise good condition by high salt intake suffers mild to moderate acidosis. The normal animal subjected to acid stress gives evidence of activation of the adrenal glands.