Studies of the LSA Ascites Lymphoma of C57B1 Mice

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Abstract
Radiation dose-survival curves have been obtained for the LSA ascites lymphoma of C57B1/Ka mice after administration of the halogenated thymidine analogue BCDR, alone or in combination with FUDR. A 7 per cent thymine replacement by BU has been obtained with BCDR-treatment alone with a sensitization factor relative to the saline-treated control of 1·7. A 14 per cent thymine replacement was obtained with combined FUDR-and BCDR-treatment. The latter treatment was accompanied by a 9-fold increase in the TD50 and a 2·4 sensitization factor to x-irradiation relative to the controls.