Ultraviolet-Mediated Cytotoxic Activity of Phenylheptatriyne From Bidens pilosa L.

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Abstract
The tropical weed B. pilosa L. (Asteraceae) contains a number of polyacetylenes which are phototoxic to bacteria, fungi and human fibroblast cells in the presence of sunlight, artificial sources of long-wave UV light, or cool-white fluorescent light. The principle photoactive compound in the leaf, phenylheptatriyne, is present in the cuticle as well as in the underlying cells. Experiments with calf thymus DNA indicate that, unlike photoactive furanocoumarins, phenylheptatriyne does not form interstrand cross linkages with DNA in UV light.