Renal damage in rats from the lead salt of edta and from umbradil

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Abstract
The histological renal changes in rats following intravenous and intra-arterial injections of lead EDTA (ethylenediaminetetraScetic acid tetrasodium salt) are briefly described. After intravenous injections, tubular epithelial degeneration with the formation of hyaline casts and mineral deposits were found. Following intra-arterial injection of EDTA, interstitial and periglomerular hemorrhage occurred in addition to moderate epithelial changes of the tubules. The lesions were similar to, but more severe than those appearing after the injection of comparable doses of umbradil (diethanolamine salt of 3, 5 diiodo-4(IH)-pyridone-l acetic acid).

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