The Inhibiting Effect of Normal Serum and Its Gamma Globulin Fraction upon the Variation of Staphylococcus aureus

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Abstract
S. aureus non-smooth variants which occur in beef extract broth were inhibited when 2% normal bovine serum or 25 mg. of bovine gamma globulin per 5 ml. of medium was added to the broth. In addition, the normal serum or its gamma globulin counteracted the enhancing effect of beef brain extract in the establishment of such variants.