Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.
- 1 February 1991
- journal article
- Vol. 138 (2) , 385-93
Abstract
Inducible cell adhesion molecule 110 (INCAM-110), is a 110-kd adhesion receptor for lymphocytes and monocytes identified on cytokine-activated endothelium. Using immunoperoxidase techniques, little or no INCAM-110 was detected on endothelium in normal human tissues. In contrast, INCAM-110 was expressed in postcapillary venules in a variety of active inflammatory processes. In acute appendicitis, INCAM-110 was found coincident with strong expression of endothelial leukocyte adhesion molecule 1 (ELAM-1), a cytokine-inducible molecule that functions in neutrophil adhesion. However, in certain chronic inflammatory processes (eg, sarcoidosis), INCAM-110 was observed without simultaneous ELAM-1 expression. Anti-INCAM-110 antibody E1/6 also marked several extravascular cell types, including lymphoid dendritic cells, some tissue macrophages, synovial lining cells, and reactive mesothelial cells. These data suggest a role for endothelial INCAM-110 in the pathophysiology of both acute and chronic inflammatory reactions. Furthermore INCAM-110 may function as an adhesion molecule for mononuclear leukocytes in a variety of extravascular sites.This publication has 45 references indexed in Scilit:
- Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110Science, 1990
- An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells.The Journal of Experimental Medicine, 1989
- Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.Journal of Clinical Investigation, 1989
- Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4αCell, 1989
- Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.Journal of Clinical Investigation, 1988
- Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specificJournal of Cellular Physiology, 1988
- Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.The Journal of cell biology, 1988
- Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.The Journal of cell biology, 1988
- Tumor Necrosis Factor (TNF)Science, 1985
- Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic CellsScience, 1985