Intravascular contrast agents suitable for magnetic resonance imaging.

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Abstract
Two paramagnetic chelates, Cr EDTA and gadolinium DTPA [diethylenetriaminepentaacetic acid), were evaluated as potential i.v. contrast agents for magnetic resonance imaging (MR) using a 0.5-T superconducting scanner. After evaluating both agents in vitro, in vivo studies were conducted in dogs to document changes in renal appearance produced by contrast injection. Acute splenic and renal infarction were diagnosed with contrast-enhanced MR, and confirmed by gamma camera imaging following administration of 99mTc-labeled DMSA and sulfur colloid. I.v. paramagnetic contrast agents presently offer the best mechanism for assessment of tissue function and changes in perfusion with MR.