Mutated variant of Candida antarcticalipase B in (S)-selective dynamic kinetic resolution of secondary alcohols
- 17 November 2010
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 9 (1) , 81-82
- https://doi.org/10.1039/c0ob00748j
Abstract
An (S)-selective dynamic kinetic resolution of secondary alcohols, employing a mutated variant of Candida antarcticalipase B (CalB) gave products in 84–88% yield and in 90–97% ee.This publication has 13 references indexed in Scilit:
- Asymmetric Synthesis of Bicyclic Diol Derivatives through Metal and Enzyme Catalysis: Application to the Formal Synthesis of SertralineChemistry – A European Journal, 2010
- Mutant Lipase-Catalyzed Kinetic Resolution of Bulky Phenyl Alkylsec-Alcohols: A Thermodynamic Analysis of EnantioselectivityChemBioChem, 2010
- (S)‐Selective Kinetic Resolution and Chemoenzymatic Dynamic Kinetic Resolution of Secondary AlcoholsChemistry – A European Journal, 2005
- An S‐Selective Lipase Was Created by Rational Redesign and the Enantioselectivity Increased with TemperatureAngewandte Chemie International Edition in English, 2005
- Creating Space for Large Secondary Alcohols by Rational Redesign of Candida antarctica Lipase BChemBioChem, 2005
- Combined Ruthenium(II) and Lipase Catalysis for Efficient Dynamic Kinetic Resolution of Secondary Alcohols. Insight into the Racemization MechanismJournal of the American Chemical Society, 2005
- (S)-Selective Dynamic Kinetic Resolution of Secondary Alcohols by the Combination of Subtilisin and an Aminocyclopentadienylruthenium Complex as the CatalystsJournal of the American Chemical Society, 2003
- One Biocatalyst–Many Applications: The Use of Candida Antarctica B-Lipase in Organic SynthesisBiocatalysis and Biotransformation, 1998
- Crystallographic and molecular-modeling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcoholsBiochemistry, 1995
- A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosaThe Journal of Organic Chemistry, 1991