DO D-600 AND DILTIAZEM INTERACT WITH SEROTONIN RECEPTORS IN RABBIT VASCULAR TISSUES

  • 1 January 1985
    • journal article
    • research article
    • Vol. 233  (3) , 830-835
Abstract
The interactive effects of Ca antagonists and response to serotonin (5-HT) in isolated rabbit aorta and basillar artery were investigated. Isolated strips of rabbit aorta and of basilar artery were studied in organ baths containing 20 ml of Krebs-buffer solution. D 600 [gallopani] or diltiazem caused paraeleld righward shifts of concentration-response curves for 5-HT in isolated rabbit aorta, but each reduced the 5-HT-induced maximum response in basilar artery. The slope values from Schlid plot analyses in aorta were 1.11 .+-. 0.05 and 1.22 .+-. 0.37 in D 600 and diltiazem, respectively. Dibenamine pretreatment caused reduction of maximum response to 5-HT in both tissues. Such reduction was diminished markedly by the presence of D 600, diltiazem or 5-HT in aorta but not in basilar artery. The antagonistic effects of D 600 and diltiazem were diminished by elevation of bath Ca in basilar artery but not in aorta. The 2 Ca entry blockers used in this study might compete with 5-HT at 5-HT receptors in rabbit aorta and the pharmacomechanical property of 5-HT receptors in rabbit aorta might be distinct from that in rabbit basilar artery.

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