Azumolene Reverses Episodes of Malignant Hyperthermia in Susceptible Swine
- 1 March 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 70 (3) , 253???255-255
- https://doi.org/10.1213/00000539-199003000-00004
Abstract
Azumolene is an analogue of dantrolene with much greater water solubility. Ten swine susceptible to malignant hyperthermia (MH) were triggered into MH episodes via the inhalation of halothane, and azumolene was effective in terminating all of the MH epiosodes. There was an inverse relationship between the dose of azumolene required to terminate the MH episode and the time it took for the pig to manifest the signs of MH. Azumolene was found to be similar in potency to dantrolene.This publication has 2 references indexed in Scilit:
- Ketamine Does Not Trigger Malignant Hyperthermia in Susceptible SwineAnesthesia & Analgesia, 1989
- Dantrolene sodium is able to reduce the resting ionic [Ca2+]i In muscle from humans with malignant hyperthermiaMuscle & Nerve, 1987