Microinvasive Carcinoma of the Uterine Cervix

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Abstract
Of 781 cervical squamous cell carcinomas, 66 or 8.4% were microinvasive cancers. Analysis indicated a progressive decrease in the incidence of outspoken cancer and an increasing frequency of microinvasive cancer. The mean age at detection for microinvasive cancer was 46.0 ± 12.7 years. Most women were asymptomatic at the time of detection and the cervical findings were either normal or nonspecific. Cellular studies contributed to the detection of microinvasive cancer. The microinvasive neoplasms did not exceed a depth of 5.0 mm. and cervical findings were either normal or nonspecific. Microinvasion originated predominantly from carcinoma in situ and/or dysplasia in the transitional zone of the anterior lip of the cervix. The extent of microinvasion increased with advancing age. The distribution and histologic features varied, depending upon the extent of microinvasion. Carcinoma in situ and coexisting carcinoma in situ and dysplasia were the predominant epitheliums of origin for microinvasive cancer. Dysplasia alone was infrequent. Certain abnormal surface and glandular epithelial features not commonly associated with carcinoma in situ and dysplasia were observed. The severity of these changes was related to the extent of the microinvasion. The 5-year survival for microinvasive cancer was 95.8%, No residual neoplasm was identified at autopsy on those who died. The remaining women are living and are free of neoplasm after surveillance of 1 to 21 years.

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