Intravenous Aminophylline Therapy for Asthma

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Abstract
• Eleven asthmatic children were given intravenous aminophylline by two methods of administration: a 6 mg/kg loading dose followed by a 1.1 mg/kg/hr continuous infusion, or a bolus of 4 mg/kg given every four hours. Expiratory flow rates (forced expiratory volume at 1 s and expiratory flow at 50% of vital capacity) were recorded at intervals for 24 hours with each regimen. Although the intermittent administration of aminophylline produced a substantial improvement, there was a significantly greater pulmonary response to continuous infusion. (Am J Dis Child 134:596-599, 1980)