Cutaneous periarteritis nodosa: immunofluorescence studies

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Abstract
The study of 10 cases of cutaneous periarteritis nodosa by direct immunofluorescence microscopy of excision biopsy specimens revealed positive findings in 9. Deposition of Ig[immunoglobulin]M was found in the vessel walls in 6 cases, and C3 [complement component 3] was observed in 4; only in 2 cases was C3 found with IgM in the vessel walls. Deposits of IgM in the superficial vessels were found in 5 cases, although only deep muscular vessels showed evidence of vasculitis in cutaneous periarteritis nodosa. Serum hepatitis B antigen was absent in the 9 cases that were tested. Positive immunofluorescence findings in superficial and deep vessels suggest that although periarteritis nodosa is characterized by an inflammatory panarteritis, occasional vasculitis of small vessels might be expected.

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