Relationships between Blood Lead Concentration and Aminolevulinic Acid Dehydratase in Alcoholics and Workers Industrially Exposed to Lead

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Abstract
Blood lead concentration (Pb-B), aminolevulinic acid dehydratase (ALAD), and γ-GT were measured in 265 workers industrially exposed to lead and in 184 patients with liver disease resulting from alcohol consumption. The first group was divided according to alcohol use, i.e., nondrinkers, moderate drinkers, and heavy drinkers. The second group was divided according to the following criteria: hepatopatic without cirrhosis, hepatopatic with compensated cirrhosis, and hepatopatic with decompensated cirrhosis. Heavy drinkers who were industrially exposed had the highest Pb-B (40.4 ± 14.6 μg/dl) and the lowest ALAD (22.2 ± 9.1 U/L). The correlations between Pb-B and ALAD show no significant change with the increase of Pb-B. In the alcoholic group, 76 patients with alcoholic liver disease without cirrhosis had the highest Pb-B (40.3–9.1 μg/dl) and ALAD the lowest (18.6 ± 7.7 U/L). The negative correlation between Pb-B and log ALAD disappeared completely in individuals with Pb-B that exceeded 50 μg/dl, independent from the seriousness of illness.