Systemic absorption and sustained effects of vaginal estrogen creams
- 14 December 1979
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 242 (24) , 2699-2700
- https://doi.org/10.1001/jama.242.24.2699
Abstract
Systemic absorption and sustained effects of two estrogen vaginal cream preparations (Premarin and Estrace) were measured in 29 postmenopausal women receiving daily applications. With both preparations, vaginal absorption of estrogens into the systemic circulation was rapid, efficient, and sustained. It is apparent that estrogen vaginal cream preparations, as widely used in clinical practice for their local effects on the vaginal mucosa, actually result in sustained high estrogen levels in the systemic circulation. The vaginal route shows promise when systemic estrogen therapy is indicated, but is dangerous when estrogen is contraindicated. (JAMA242:2699-2700, 1979)This publication has 4 references indexed in Scilit:
- Absorption of Estrogens from Vaginal CreamsNew England Journal of Medicine, 1978
- Efficacy of Intravaginal and Intranasal Administration of Micronized Estradiol-17β1Journal of Clinical Endocrinology & Metabolism, 1977
- VAGINAL ABSORPTION OF ESTRONE AND 17BETA-ESTRADIOL1977
- Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptivesAmerican Journal of Obstetrics and Gynecology, 1977