Studies on"Inchinko."I. : Capillarisin, a New Choleretic Substance

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Abstract
A new choleretic substance, capillarisin (I), was isolated from the herb of Artemisia capillaris Thunb (Japanese name, "Inchinko"), by tracing activity in rats. By heating with 1% NaOH or H2SO4 in methanol, I was cleaved to p-hydroquinone and a compound (XI) or p-hydroquinone and the compound (XII). IR and UV spectra suggested that I and XI are chromone derivatives and XII is a coumarin derivative. Positions of the functional groups in XI and XII were determined by direct comparison with the synthetic samples, and the structure of I was established as 2-(p-hydroxyphenoxy)-6-methoxy-5,7-dihydroxychromone.

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