Alpha1‐adrenoceptor subtypes in the human prostate

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Abstract
Objective To determine the subset of α1-adrenoceptors mediating the functional abstraction of the prostate to noradrenaline. Materials and methods Radioligand experiments were performed with membranes prepared from rat 1 fibroblasts trasfected with rat α1a, hamster α1b or bovine α1c adrenoceptor cDNA. Human prostatic tissue obtained from transurethral resection of the prostate with full informed consent was submitted to functional in vitro muscle strip experiments. Results The binding experiments defined the potential subtype selectivity of various antagonists. Using this information, it was possible to define the functionally important α1-adrenoceptor subtype in the human prostate. Conclusion This work reports the results of the first functional characterization of the α1c-adrenoceptor subtype. The most functionally important α1-ceptor type in the human prostate appears to be the α1c subtype. This finding may aid the development of prostate-selective adrenoceptor pharmacotherapy.