Oestradiol-17 both inhibits and stimulates myometrial activity in ewes in vivo

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Abstract
Spontaneous intrauterine pressure cycles were abolished for periods of several hours in ovariectomized non-pregnant ewes within 8 h of an injection of 50 .mu.g estradiol-17.beta.. Following the quiescent period, a phase of intense uterine activity ensued for several hours before again being replaced by several hours of quiescence. This active/inactive cycle disappeared after 2-4 days if further daily injections of estradiol were not given. During the quiescent periods the uterus retained its responsiveness to oxytocin and prostaglandin F2.alpha.. Increasing the dose of estradiol failed to prolong the periods of quiescence.