THE INABILITY OF PURIFIED OR CRUDE KIDNEY EXTRACT (RENIN) TO REDUCE THE BLOOD PRESSURES OF HYPERTENSIVE DOGS

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Abstract
Seven dogs were subjected to various procedures which resulted in an exptl. renal hypertension. Three of these dogs were then treated for 4 mos. with purified renin extract (daily, subcut. inj.), and 4 dogs were injected with a crude kidney extract prepared according to the method described by Wakerlin and Johnson. The daily, prolonged inj. of either purified renin or crude kidney extract had no significant effect upon the blood pressure of the hypertensive dogs and also did not increase the anti-renin content of their blood. The daily dosage of renin (either as purified or crude extract) was equivalent to one g. of fresh kidney cortex per kg. of body wt.

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