Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon

15 March 1983

journal article
research article
Published by Portland Press Ltd. in Biochemical Journal

Vol. 210 (3) , 957-960
https://doi.org/10.1042/bj2100957

Abstract

Adrenaline [epinephrine] (through .alpha.1-adrenoceptors), vasopressin and angiotensin II stimulate rat mitochondrial glutaminase activity. This stimulation probably contributes to the ureogenic effect of these hormones. The activity of the enzyme is sensitive to Ca2+ depletion. A role of Ca2+ in hormonal modulation of glutaminase activity is suggested.

This publication has 15 references indexed in Scilit:

alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.
Journal of Biological Chemistry, 1981
α1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes
European Journal of Pharmacology, 1981
The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions
Biochemical Journal, 1981
Ferroactivator and the Regulation of Gluconeogenesis
Published by Elsevier ,1981
The Relationship between Intramitochondrial N‐Acetylglutamate and Activity of Carbamoyl‐Phosphate Synthetase (Ammonia)
European Journal of Biochemistry, 1980
Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with α-adrenergic agonists and with glucagon
Biochemical Journal, 1980
The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production
Archives of Biochemistry and Biophysics, 1980
Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.
Journal of Biological Chemistry, 1980
The effects of ammonium chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria
Biochemical Journal, 1978
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS
The Journal of cell biology, 1969