A Simple Method of Protecting a Secondary Amine with Tert Butyloxycarbonyl (Boc) in the Presence of a Primary Amine
- 1 August 1992
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 22 (16) , 2357-2360
- https://doi.org/10.1080/00397919208019091
Abstract
A simple method for chemically differentiating primary and secondary amines is described in which the primary amine is condensed with benzaldehyde to form an imine leaving the secondary amine available to be protected with BOC. The imine is then hydrolyzed to provide the free primary amine.Keywords
This publication has 1 reference indexed in Scilit:
- N-acylation of 1,3-dimethyl-6-aminouracils. A reversal in the regiospecificity of an electrophilic substitution induced by an intramolecular proton-transferJournal of Heterocyclic Chemistry, 1984