Synthesis of an S-linked glycopeptide analog derived from human Tamm–Horsfall glycoprotein

Abstract
Direct base catalyzed S-glycosylation of a cysteine and a homocysteine containing peptide with O-acetyl protected bromides in DMF–water solution furnished two glycopeptide fragments. The two glycopeptide fragments were linked to the target glycopeptide with two S-glycosyl residues mimicking a part of Tamm–Horsfall glycoprotein.