Effects of Chronic Right Ventricular Volume and Pressure Loading on Left Ventricular Performance

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Abstract
The effects of chronic right ventricular (RV) distension on left ventricular (LV) function were assessed in dogs 3 weeks after pressure and volume loading of the RV had been produced by the emplacement of a constricting band around the pulmonary artery and the creation of tricuspid insufficiency. This resulted in ascites, RV hypertrophy and dilatation, an increase in RV end-diastolic pressure (EDP), and a reduction of RV and LV norepinephrine concentrations. Peak LV pressure, wall stress, and dp/dt were measured during isovolumic beats at LVEDP's of 1 to 20 mm Hg, and comparisons at matched EDP's were made among the normal, sham-operated, and RV stressed dogs. Under these circumstances, LV function appeared to be depressed appreciably. The effects of RV volume loading on the pressure-volume curve of the LV in the potassium-arrested heart were assessed in a separate group of dogs. The pressure-volume curve of the LV was shifted so that any given LV volume was associated with a higher LV pressure. Thus, whe...

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