Effect of angiotensin II on secretion of adrenal androgens.

Publisher Website
Google Scholar
Abstract
To assess the effect of angiotensin II (A II) on the secretion of human adrenal androgens (AA), plasma dehydroepiandrosterone (DHEA), DHEA sulfate (DS) and .DELTA.4-androstenedione (.DELTA.4-A) were measured in 8 normal men 60 and 120 min after stimulation of endogenous A II by a bolus injection of 40 mg frusemide; the direct effect of A II on the secretion of adrenal androgens was examined in cultured human adrenocortical cells in the presence of a low concentration of ACTH. The administration of frusemide led to a significant increase in the plasma DHEA and DS concentration as well as plasma renin activity (PRA) and aldosterone concentration (PAC), but did not change plasma cortisol and .DELTA.4-A. In the culture of human adrenocortical cells, 10-9-10-5 M A II or 10-13 M ACTH alone did not stimulate the secretion of DHEA, DS and .DELTA.4-A, while 10-7 and 10-5 M A II in the presence of 10-13 M ACTH caused a significant increase in DHEA and DS secretion with no change in .DELTA.4-A. Apparently, the activated renin-angiotensin system stimulates the secretion of adrenal androgens by a direct effect of A II on adrenal cortical cells.

This publication has 1 reference indexed in Scilit: