An Experimental Study on the Effect of Reticulo-endothelial Activity on Metastasis and Recurrence of Tumor

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Abstract
This paper provides experimental evidence to show that the susceptibility of regional lymph nodes to tumor metastasis is significantly modified by the reticuloendothelial function of the host. When untreated C3H mice were inoculated with ascites hepatoma MH 134 and the tail amputated after 10 days, 46.4% of the animals died of recurrent tumor, the site of recurrence being the sciatic nodes that are regional to the tail. However, the rate of recurrence was lowered to 16.1 % when the RES [reticuloendothelial system] of the animals was activated by treatment with typhoid vaccine. The rate in animals with their RES depressed by prednisolone was 58.3%, a little higher than the control level. Hyperplasia of reticuloendothelial cells of the sciatic nodes was common in animals that escaped tumor recurrence this was particularly prominent in those treated by typhoid vaccine, suggesting that this pattern of lymph node reaction represents RES activity of the host and is an indication of host resistance.