THE ENZYMATIC ACTIVATION OF AMINO ACIDS VIA THEIR ACYL-ADENYLATE DERIVATIVES
- 1 June 1956
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 42 (6) , 325-332
- https://doi.org/10.1073/pnas.42.6.325
Abstract
Synthesis of certain amino acyl-AMP compounds is described, and some of the properties of such compounds indicated. Rapid formation of adenosine triphosphate (ATP) from leucyl-AMP and inorganic pyrophosphate by a purified extract of Escherichia coli which catalyzes the leucine-dependent exchange of pp32 and ATP is reported. This finding suggests that amino acyl-AMP compounds are intermediates in the exchange reaction. The properties of these compounds as well as those of the enzyme system are discussed in relation to their possible participation in protein synthesis.This publication has 8 references indexed in Scilit:
- ENZYMATIC CARBOXYL ACTIVATION OF AMINO ACIDSPublished by Elsevier ,2021
- An amino acid dependent exchange between inorganic pyrophosphate and ATP in microbial extractsBiochimica et Biophysica Acta, 1955
- An enzymic mechanism for amino acid activation in animal tissuesBiochimica et Biophysica Acta, 1955
- A COLORIMETRIC DETERMINATION OF INORGANIC PYROPHOSPHATEJournal of Biological Chemistry, 1954
- Phosphate Anhydrides of Amino AcidsJournal of the American Chemical Society, 1954
- THE EFFECT OF ARSENATE ON AEROBIC PHOSPHORYLATIONJournal of Biological Chemistry, 1953
- A MODIFIED PHOTOMETRIC NINHYDRIN METHOD FOR THE ANALYSIS OF AMINO AND IMINO ACIDSJournal of Biological Chemistry, 1953
- DIFFERENTIAL SPECTROPHOTOMETRY OF PURINE COMPOUNDS BY MEANS OF SPECIFIC ENZYMES .1. DETERMINATION OF HYDROXYPURINE COMPOUNDS1947