THE TIMING OF HISTOLOGICAL DAMAGE FOLLOWING A SINGLE CHALLENGE WITH GLUTEN IN TREATED CELIAC-DISEASE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 50  (197) , 83-94
Abstract
Two treated subjects and 1 healthy volunteer were challenged with a single dose of fraction B gluten administered intraduodenally. Serial biopsy specimens were obtained before challenge and repeatedly thereafter. The biopsy specimens were studied by light microscopy, EM, immunofluorescence, immunoperoxidase staining and disaccharidase assay. The 2 celiac subjects showed pronounced mucosal changes which developed a few h after challenge and which showed the features of an Arthus-type reaction. The healthy volunteer was unaffected. The lesion of celiac disease is evidently the result of an Arthus-type reaction induced by ingested gluten in susceptible subjects.