Adult tissues contain chemo-attractants for vascular endothelial cells

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Abstract
New blood vessel formation, or angiogenesis, occurs through the migration of endothelial cells in elongated sprouts. These sprouts are directed preferentially towards the inciting stimulus. Certain chemical substances have been shown to stimulate angiogenesis. Endothelial cell migration towards the chemical stimulus may be due to a preferential migration of cells from lower to higher concentrations of the mediator. Such concentration gradient-dependent cellular migration was termed chemotaxis. A modification of the Boyden chamber technique was used to measure chemotaxis in vitro. Extracts of various adult bovine tissues have potent chemotactic activity for vascular endothelial cells. Adult bovine serum lacks similar chemotactic activity.