Peptide-Cleaving Catalyst Selective for Peptide Deformylase
- 2 February 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (8) , 2396-2397
- https://doi.org/10.1021/ja044043h
Abstract
A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)−Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF.Keywords
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