Reduction of Erythrocyte (Na+-K+)ATPase Activity in Type 2 (Non-Insulin-Dependent) Diabetic Patients with Microalbuminuria

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Abstract
In order to elucidate the causal relationship between (Na+-K+)ATPase and diabetic nephropathy, we studied the erythrocyte (Na+-K+)ATPase activity in Type 2 diabetic patients, 20 with microalbuminuria and 27 without microalbuminuria and in 16 control subjects. (Na+-K+)ATPase activities in microalbuminuric patients (0.273 ± 0.012 μmol Pi/mg protein/h, mean ± SE) were significantly reduced compared with those without microalbuminuric patients (0.308 ± 0.011 μmol Pi/mg protein/h, p+-K+)ATPase activities in diabetic patients with hypertension were significantly reduced compared with those in diabetic patients without hypertension. Moreover, (Na+-K+)ATPase activities in diabetic patients with parental hypertension were significantly reduced compared with those in patients without parental hypertension. There was no difference in erythrocyte Na+ content between with and without microalbuminuria or hypertension or parental hypertension in diabetic patients. Erythrocyte Na+ content was significantly negatively correlated with (Na+-K+)ATPase activity in control subjects (r = -0.619, p+-K+)ATPase activities in diabetic patients with microalbuminuria or hypertension or parental hypertension. We concluded that the reduction of erythrocyte (Na+-K+)ATPase activity may be related to a familial predisposition to arterial hypertension and may partly be responsible for the development of diabetic nephropathy in Type 2 diabetic patients.

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