Beta-Adrenergic Receptor Blocking Drugs

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Abstract
Cardiac ArrhythmiasShortly after their development, attempts were made to determine the effects of beta-adrenergic receptor blocking agents on variovis types of experimentally induced cardiac arrhythmias. It was soon found that the drugs effectively antagonized arrhythmias induced by catecholamines65 66 67 68 and digitalis69 70 71 72 73 in laboratory animals. The first clinical report on the use of beta-adrenergic blocking drugs in the treatment of cardiac arrhythmias was in 1963, when Stock and Dale74 observed that pronethalol effectively slowed the ventricular rate in patients with atrial fibrillation and suppressed several types of arrhythmias caused by digitalis toxicity.Digitalis-Induced ArrhythmiasThere appears to be little doubt that . . .