ANTAGONISM OF KETAMINE-DIAZEPAM ANAESTHESIA BY 4-AMINOPYRINDINE IN HUMAN VOLUNTEERS

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Abstract
Five healthy human volunteers were anasthetized on two separate occasions, 1 week apart, using a standard diazepam-ketaminc induction followed by an infusion of ketamine for 1 h. Ten minutes after stopping the infusion, either 4-aminopyridine 0.3 mg kg−1 in saline or the same volume of saline alone was administered i.v. It was concluded that 4-aminopyridine enhanced dramatically the rate of recovery of the subjects to full consciousness and normal motor coordination when compared with the sadine controls.