Multicellular Origin of Parathyroid Adenomas
- 5 January 1978
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (1) , 53-54
- https://doi.org/10.1056/nejm197801052980116
Abstract
To the Editor: The conclusion of Fialkow et al. (N Engl J Med 297:696–698, 1977), based on their G-6-PD analysis of parathyroid tissue, that parathyroid hyperplasias and adenomas "may...be similar biologically" is hardly justified by their presented data. As Fialkow himself points out elsewhere, "before concluding that a tumor...contains both enzyme types (B & A) and thus has a multiple cell origin, the possibility must be considered that the actual tumor cells have a single-enzyme phenotype, and that the second enzyme type is due to the presence of non-neoplastic cells admixed with the tumor cells."1 Specifically, their estimates of less . . .Keywords
This publication has 2 references indexed in Scilit:
- Semipermeable membranes for improving the histochemical demonstration of enzyme activities in tissue sectionsHistochemistry and Cell Biology, 1974
- Evidence for a clonal origin of head and neck tumorsInternational Journal of Cancer, 1972