Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters: Effects of adrenalectomy and corticosteroid implants
- 28 February 1985
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 64 (1) , 67-79
- https://doi.org/10.1007/bf01259346
Abstract
Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the activities of the enzymes N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were implanted with the appropriate corticosteroid or adrenalectomized two weeks earlier. Melatonin content and NAT activity were increased at 4 hours (during darkness) in adrenalectomized hamsters; conversely, no alterations in melatonin levels were observed in either adrenalectomized or implanted rats. It is suggested that the changes in adrenal function probably have a minor influence on pineal melatonin production.Keywords
This publication has 24 references indexed in Scilit:
- Applied Statistics for the Behavioral SciencesJournal of Educational Statistics, 1990
- Concurrent determination of enzymatic activities and substrate concentrations in the melatonin synthetic pathway within the same rat pineal glandJournal of Neuroscience Research, 1984
- Regulation of Rat Pineal Hydroxyindole‐O‐Methyltransferase in Neonatal and Adult RatsJournal of Neurochemistry, 1983
- Twenty-four hour melatonin secretory pattern in men with idiopathic hemochromatosisPsychoneuroendocrinology, 1983
- Regulation of Rat Pineal Hydroxyindole-O-Methyltransferase: Evidence of S-Adenosylmethionine-Mediated Glucocorticoid ControlJournal of Neurochemistry, 1980
- Determination of tryptophan and metabolites in rat brain and pineal tissue by reversed-phase high-performance liquid chromatography with electrochemical detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- The adrenal medulla may mediate the increase in pineal melatonin synthesis induced by stress, but not that caused by exposure to darknessJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1977
- Factors other than Light Affecting the Pineal Gland: Hypophysectomy, Testosterone, Dihydrotestosterone, Estradiol, Cryptorchidism, and StressAmerican Zoologist, 1976
- Radioautographic study of the rat brain and pituitary after injection of 3H dexamethasoneCell and tissue research, 1975
- The effect of thyroxine and cortisol on some dehydrogenases and lysosomal enzymes activities in rat pineal culturesHistochemistry and Cell Biology, 1968