The Effects of Oophorectomy and Long-Term Mestranol Therapy on the Serum Lipids of Middle-Aged Women

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Abstract
1. Serum lipid concentrations were measured in groups of women who had undergone oophorectomy and hysterectomy or hysterectomy alone. Measurements were repeated in some of the oophorectomized women after treatment for 1 year with either mestranol or a placebo. 2. A significant correlation was found between serum cholesterol concentrations and age in the women with intact ovaries. Although such a correlation was not apparent in the oophorectomized women, the younger women in this group had significantly higher cholesterol concentrations than the younger women with intact ovaries. 3. A significant correlation was found between serum triglyceride concentration and age in both groups of women, but the oophorectomized women showed a significantly slower rate of increase of triglyceride with age than women with intact ovaries. 4. Administration of 20–40 μg of mestranol daily for 1 year was associated with a significant fall in serum cholesterol and a significant rise in serum triglyceride.

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