Rheumatoid and Lupus-Erythematosus-like Syndromes

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Abstract
During the past two years hydralazine hydrochloride (1-hydrazinophthalazine hydrochloride; Apresoline) has been used extensively in the treatment of hypertension. Its reputed ability to reduce arterial pressure through its central action1and to increase renal circulation2accounts in part for its usefulness as an antihypertensive agent. A syndrome, however, appeared among patients using hydralazine, with symptoms which ranged from mild migratory arthralgic pains to symptoms resembling early acute rheumatoid arthritis or acute systemic lupus erythematosus, according to Dustan and his group*and to Perry and Schroeder.† Other isolated cases reported in the recent literature include those of Manter,7Feder,8Reinhardt and Waldron,9and Shackman and associates.10Kaufman11reported a case of pancytopenia due to hydralazine. This report is an analysis of the late reactions in a group of patients treated with oral administrations of hydralazine

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