One-step synthesis of 5′-azido-nucleosides
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 306-310
- https://doi.org/10.1039/p19800000306
Abstract
Regioselective azidation of unprotected or appropriately protected nucleosides was conducted by means of the reagent triphenylphosphine–carbon tetrabromide–lithium azide. By use of this reagent, 5′-azido-5′-deoxynucleosides were prepared conveniently in one step from nucleosides in high yields. Secondary hydroxy-groups of appropriately 5′-protected nucleosides were also converted by the reagent to azido-functions with complete inversion.Keywords
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