Short- and Long-Term Regulation of Tyrosine Hydroxylase in Chromaffin Cells by VIP and PACAPa
- 17 December 2006
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 805 (1) , 219-230
- https://doi.org/10.1111/j.1749-6632.1996.tb17485.x
Abstract
Whereas cholinergic neurotransmitters are responsible for the release of a substantial portion of the CAs released from rat chromaffin cells by activation of the splanchinc nerves, the present data suggest that noncholinergic neurotransmission appears to play a more substantial role in the short- and long-term homeostatic regulation of TH activity, which serves to maintain the stores of CAs for subsequent release. In addition, studies using the PKA-deficient PC12 cells provided the first direct evidence that PKA actually mediates the phosphorylation of Ser40 in situ.Keywords
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