Cross-Reactivity between Borrelia burgdorferi Flagellin and a Human Axonal 64,000 Molecular Weight Protein
- 1 June 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 167 (6) , 1372-1378
- https://doi.org/10.1093/infdis/167.6.1372
Abstract
The serum of patients with Lyme neurologic disease contain antibodies that bind to human axonal antigens that cross-react with Borrelia burgdorferi. The sera also bind to SK-N-SH neuroblastoma cells, especially the neuritic processes of these cells. H9724, a murine IgG monoclonal antibody to B. burgdorferi flagellin, binds to an SK-N-SH cell protein of ∼64,000 apparent molecular weight (Mr) . H9724 immunoprecipitates a protein of the same M, (p64) from the cells and from a delipidated preparation of human peripheral nerve. The Lyme disease patient sera that bind to human axons and SK-N-SH cells also bind to the immunoprecipitated p64. Immunologic cross-reactivity between borrelial and human axonal proteins may be involved in the immunopathogenesis of Lyme neurologic disease.Keywords
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