Effect of Nitrous Oxide on the White-Cell Count in Leukemia
- 7 February 1963
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 268 (6) , 297-299
- https://doi.org/10.1056/nejm196302072680607
Abstract
TOXICITY from nitrous oxide has been assumed to be entirely the effect of associated reduction of oxygen tension. Goldman,1 in 1928, reported the intermittent administration of nitrous oxide to rats and mice during a two-month study. He observed no deleterious effects. The first indication that nitrous oxide might have a toxic effect to man came in 1955, when Gormsen2 presented the results of treatment of a case of tetanus in which nitrous oxide was used along with chlorpromazine and curare. The thrombocytopenia and leukopenia occurring on the fifth day of treatment were attributed to curare.Mollaret,3 in the same year, . . .This publication has 7 references indexed in Scilit:
- A SEVERE CASE OF TETANUS SHOWING INTERESTING FEATURESBritish Journal of Anaesthesia, 1962
- BONE-MARROW DEPRESSION FOLLOWING TREATMENT OF TETANUS WITH PROTRACTED NITROUS-OXIDE ANÆSTHESIAThe Lancet, 1958
- The Cytotoxic Effect of Nitrous Oxide at Different Oxygen Tensions*).Acta Pharmacologica et Toxicologica, 1957
- BONE-MARROW DEPRESSION IN TETANUS: REPORT OF A FATAL CASEThe Lancet, 1956
- THE TREATMENT OF TETANUS BY SEDATION, CURARIZATION AND INTRATRACHEAL POSITIVE‐PRESSURE ARTIFICIAL RESPIRATION, WITH REPORT OF A CASEThe Medical Journal of Australia, 1956
- TREATMENT OF TETANUS SEVERE BONE-MARROW DEPRESSION AFTER PROLONGED NITROUS-OXIDE ANESTHESIAThe Lancet, 1956
- Conclusions from Extended Experiments with Nitrous Oxid, Acetylene and Ethylene-Oxygen Anesthesia*Anesthesia & Analgesia, 1928