The Effect of Dicumarol on the Transvascular Exchange of T-1824-Labeled Protein in Rabbits

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Abstract
The effect of Dicumarol on the peritoneal transvascular transfer of T-1824-labeled plasma protein was investigated in the intact rabbit by a specially designed method. A significantly increased transfer rate was found in animals given two injections of Dicumarol 48 and 24 hours prior to testing; but determinations made 3 hours after a single injection demonstrated variable susceptibility to the drug. Prothrombin levels were depressed in every case.