Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic OphiuroidOphioderma longicaudum
- 1 November 1993
- journal article
- research article
- Published by Taylor & Francis in Natural Product Letters
- Vol. 3 (3) , 197-201
- https://doi.org/10.1080/10575639308043863
Abstract
Two novel sulphated polyhydroxysteroids, 1, possessing potent cytotoxic activity, and 2, which proved to be cytoprotective against HIV-1, have been isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known tetrol disulphated 3. The structures of 1 and 2 have been determined to be cholest-5-ene-2α,3α,4β, 21-tetraol 3, 21-disulphate and cholest-5-ene-2β,3α, 21-triol 2, 21-disulphate, respectively.Keywords
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