Influence of Mammary Tumor Virus Infection on the Acceptance or Rejection of Transplanted ML+ Leukemias

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Abstract
ML(mammaryleukemia) cellular antigen,- defined by specific cytotoxic antisera, is present on the cells of mammary tumors of MTV [mammary tumor virus]-infected mice and on the cells of some DBA/2 leukemias (ML + leukemias). Transplants of ML+ leukemias are rejected by genotypically histocompatible mice not infected with MTV, but not by MTV-infected mice of the same genotype. Heightened resistance to transplants of mammary tumors can be transferred to recipient mice by immuno-logically competent cells from donors that have rejected ML+ transplanted leukemias.