PHARMACOKINETICS OF LIGNOCAINE IN CHILDREN FOLLOWING CAUDAL ANAESTHESIA
Open Access
- 1 December 1984
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 56 (12) , 1399-1402
- https://doi.org/10.1093/bja/56.12.1399
Abstract
The time course of the plasma lignocaine concentration, following caudal anaesthesia, was studied in 11 healthy children (3.5–9 yr). Plasma lignocaine concentrations were measured for up to 6 h after administration (5 mg kg−1). Peak plasma concentration was 2.05+0.08 μ ml−1 and occurred at 28.2±2.9 min after administration. Pharmacokinetic parameters determined from a two-compartmental model were similar to those observed after the i.v. or extradural administration of lignocaine in adults, except for a longer half-life of elimination (155±32 min). Since the total body clearance of lignocaine was similar in children (15.4±1.2 ml min−1 kg−1) to that in adults, the longer half-life of elimination was attributed to a larger volume of distribution in the children (3.05 ±0.40 litre kg−1).This publication has 0 references indexed in Scilit: