Effect of Glucocorticoids on Lipoprotein Lipase Activity in Rat Heart and Adipose Tissue

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Abstract
Adipose tissue lipoprotein lipase activity in either fed or fasting rats was increased by glucocorticoid injection and decreased by adrenalectomy. The difference in enzyme activity between fed and fasting animals was unchanged by adrenalectomy. Heart lipoprotein lipase activity in fed rats was increased by a single injection of glucocorticoid to the high level usually found in fasting rats. The rise in activity induced by fasting was reduced by adrenalectomy. The results suggest that the nutritional regulation of lipoprotein lipase activity in heart may partly be ascribed to glucocorticoids.