Targeted Delivery of Drugs Provided by Water-Soluble Polymeric Systems with Low Critical Solution Temperature (LCST
- 1 January 1994
- journal article
- research article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 9 (1) , 55-65
- https://doi.org/10.1177/088391159400900103
Abstract
A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The method involves the immobilization of these compounds on a water-soluble polymer with a low critical solution temperature and heating the delivery site above the critical temperature. The approach was illustrated with trypsin immobilized on N-isopropylacrylamide-acrylamide-N-acryloylphthalimide ternary copoly mers.Keywords
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