Preimplantation Genetic Diagnosis

Publisher Website
Google Scholar
Abstract
Detecting fetal disorders in utero has long been a goal of obstetrics. In 1956 sex-chromatin analysis was performed on amniotic-fluid cells to determine fetal sex in pregnancies at risk for X-linked recessive traits. In 1968 the first prenatal diagnosis of trisomy 21 was made by analysis of cultured amniotic-fluid cells. The accuracy and safety of amniocentesis performed at or after 15 weeks' gestation were soon established. A collaborative study conducted by the National Institute of Child Health and Human Development from 1972 through 1975 showed no increase in fetal losses among pregnant women who underwent amniocentesis as compared with those . . .